Clostridium difficile antigen GDH

CLIA is a revolutionary and high-sensitive immunodiagnostic technique, that represents a huge step in diagnosis of both infectious and non-infectious diseases.

Clostridium difficile (CD) is an anaerobic, gram-positive bacterium that can produce a spectrum of gastrointestinal diseases, ranging from pseudomembranous colitis to diarrhoea to toxic megacolon. However, many healthy individuals have this bacterium in their organism, as the disease and clinical manifestations only occur when C.dificile proliferates in the colon and produces toxins A and B. Reasons why this proliferation occurs remain unknown, but it is associated with antibiotic abuse, that can destroy intestinal microbiota.

Main symptoms of CD infection are fever, abdominal pain, diarrhoea and pseudomembranous colitis. In addition, CD has a high antimicrobial resistance, related to their ability to produce spores.

CerTest Biotec CLIA detects GDH protein in stool samples of patients. GDH is an enzyme produced by toxigenic C.dificile, that it is more stable and easy to detect than toxins A and B.